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    Moustafa Gabr, PhD

    Precise health starts with precise diagnosis

  • About Moustafa

    Moustafa received his B.S.c in pharmaceutical sciences from Mansoura University, Egypt in 2011. During his undergraduate studies he participated in a research internship at Chinese Academy of Sciences. His research focused on applications of ruthenium complexes as electrochemiluminescence reagents. Also as an undergraduate student, Moustafa actively investigated three dimensional structure of actinoporin sticholysin I in his research internship at Complutense University of Madrid.

     

    Moustafa pursued a Master's degree in medicinal chemistry in a joint program between Georgia State University and Mansoura University. At Binghe Wang's lab in GSU, he designed small molecules as potential anticancer therapeutics through EGFR kinase inhibition. His research was recognized by a research symposium award from Royal Society of Chemistry (RSC) and an invited talk at the Young Members Symposium of RSC in 2014.


    In 2019, Moustafa earned his PhD in chemistry from University of Iowa under the supervision of Prof. Christopher Pigge. His multidisciplinary research focused on early diagnosis through development of fluorescent probes for biomarkers of diseases. His research was recognized by Lynn Anderson Research Excellence Award from University of Iowa in 2018. He also received travel awards from ACS organic and inorganic divisions to present his PhD research in 2018 and 2019, respectively

     

    Moustafa's ultimate goal is to establish a research program focusing on questions at the interface of chemistry and biology. Interdisciplinary research in this area focuses on using tools of chemistry to address questions in biology and vice versa. Instead, his research plan is to develop new experimental approaches for these questions. His long-term career goal is to establish close ties between his academic research and industry that would eventually be translated into public benefit.

  • Education and Training

    University of Iowa

    2014-2019

    PhD in chemistry

    Advisor: Prof. Christopher Pigge

    Project: Tetraarylethylenes for biosensing applications

    Georgia State University

    2012-2013

    Research Intern

    Advisor: Prof. Binghe Wang

    Project: Design and synthesis of EGFR kinase inhibitors as potential anticancer theraputics

    Mansoura University

    2014

    Master's degree in medicinal chemistry

    Mansoura University

    2011

    Bachelor of Pharmaceutical Sciences

    Complutense University of Madrid

    2011

    Advisor: Prof. Alvaro Martinez-del-pozo.

    Project: Three dimensional structure of actinoporin sticholysin I. Influence of long distance effects on protein function.

    Chinese Academy of Sciences

    2010

    Advisor: Prof. Guobao Xu

    Project: Applications of ruthenium(II) complexes as electrochemiluminescence reagents.

  • Publications

    Peer-reviewed papers

     

    1. Gabr, M. T. and Pigge, F. C. Platinum(II) complexes with sterically expansive tetraarylethylene ligands as probes for DNA mismatches. Inorg. Chem. 2018, 57, 12641-12649.

     

     

     

    2. Gabr, M. T. and Pigge, F. C. Rhenium complexes of bis(benzothiazole)-based tetraarylethylenes as selective luminescent probes for amyloid fibrils. Chem. Eur. J. 2018, 24, 11729-11737.

     

     

    3. Gabr, M. T. and Pigge, F. C. A fluorescent turn-on probe for cyanide anion detection based on an AIE active cobalt(II) complex. Dalton Trans. 2018, 47, 2079-2085.

     

     

    4. Gabr, M. T. and Pigge, F. C. Salts and co-crystalline assemblies of tetra(4-pyridyl)ethylene with di-carboxylic acids. Crystals, 2018, 8, 41.

     

     

    5. Gabr, M. T.* and Abdel-Raziq M. S. Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors. Bioorg. Med. Chem. Lett. 2018, 28, 2910-2913. (* corresponding author)

     

     

    6. Gabr, M. T.* and Abdel-Raziq M. S. Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors. Bioorg. Chem. 2018, 80, 245-252. (* corresponding author)

     

     

    7. Gabr, M. T.* and Abdel-Raziq M. S. Synthesis, anticancer activity and autophagic flux inhibition of new arylsparteine derivatives. Phytochem. Lett. 2018, 27, 203-207. (* corresponding author)

     

     

    8. Gabr, M. T.* and Abdel-Raziq M. S. Structure-based design and synthesis of fluorene derivatives as novel RORgt inverse agonists. Chem. Biodivers. 2018, 15, e1800244. (* corresponding author)

     

     

    9. Gabr, M. T.; El-Gohary, N. S.; El-Bendary, E. R.; El-Kerdawy, M. M.; Ni, N. Microwave-assisted synthesis, antimicrobial, antiquorum-sensing and cytotoxic activities of new series of isatin-b-thiocarbonohydrazones. Synth. Commun. 2018, 48, 2899-2911.

     

     

    10. Gabr, M. T.* and Abdel-Raziq M. S. Pharmacophore-based tailoring of biphenyl amide derivatives as selective 5-hydroxytryptamine 2B receptor antagonists. Med. Chem. Commun. 2018, 9, 1069-1075. (* corresponding author)

     

    11. Gabr, M. T.* Antioxidant, α-glucosidase inhibitory and in vitro antitumor activities of coumarin-benzothiazole hybrids. Heterocycl. Commun. 2018, 24, 243-247. (* corresponding author)

     

    12. Gabr, M. T. and Pigge, F. C. Rhenium tricarbonyl complexes of AIE active tetraarylethylene ligands: tuning luminescence properties and HSA-specific binding. Dalton Trans. 2017, 46, 15040-15047.

     

    13. Gabr, M. T. and Pigge, F. C. A turn-on AIE active fluorescent sensor for Hg2+ by combination of 1,1-bis(2-pyridyl)ethylene and thiophene/bithiophene fragments. Mater. Chem. Front. 2017, 1, 1654-1661.

     

    14. Gabr, M. T.; El-Gohary, N. S.; El-Bendary, E. R.; El-Kerdawy, M. M.; Ni, N. Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives. EXCLI J. 2017, 16, 1114-1131.

     

    15. Gabr, M. T.; El-Gohary, N. S.; El-Bendary, E. R.; El-Kerdawy, M. M.; Ni, N. Isatin-β-thiocarbohydrazones: Microwave-assisted synthesis, antitumor activity and structure-activity relationship. Eur. J. Med. Chem. 2017, 128, 36-44.

     

    16. Gabr, M. T. and Pigge, F. C. A selective fluorescent sensor for Zn2+ based on aggregation-induced emission (AIE) activity and metal chelating ability of bis(2-pyridyl)diphenylethylene. Dalton Trans. 2016, 45, 14039-14043.

     

    17. Reedy, J. L.; Hedlund, D. K.; Gabr, M. T.; Henning, G. M.; Pigge, F. C.; Schultz, M. K. Synthesis and evaluation of tetraarylethylene-based mono-, bis-, and tris(pyridinium) derivatives for image-guided mitochondria-specific targeting and cytotoxicity of metastatic melanoma cells. Bioconjugate Chem. 2016, 27, 2424-2430.

     

    18. Gabr, M. T.; El-Gohary, N. S.; El-Bendary, E. R.; El-Kerdawy, M. M.; Ni, N. Synthesis, in vitro antitumor activity and molecular modeling studies of a new series of benzothiazole Schiff bases. Chin. Chem. Lett. 2016, 27, 380-386.

     

    19. Gabr, M. T. and Pigge, F. C. Synthesis and aggregation-induced emission properties of pyridine and pyridinium analogues of tetraphenylethylene. RSC Adv. 2015, 5, 90226-90234.

     

    20. Gabr, M. T.; El-Gohary, N. S.; El-Bendary, E. R.; El-Kerdawy, M. M.; Ni, N. Synthesis, antimicrobial, antiquorum-sensing and cytotoxic activities of new series of benzothiazole derivatives. Chin. Chem. Lett. 2015, 26, 1522-1528.

     

    21. Gabr, M. T.; El-Gohary, N. S.; El-Bendary, E. R.; El-Kerdawy, M. M. Structure-based drug design and biological evaluation of 2-acetamidobenzothiazole derivative as EGFR kinase inhibitor. J. Enzyme Inhib. Med. Chem. 2015, 30, 160-165.

     

    22. Gabr, M. T.; El-Gohary, N. S.; El-Bendary, E. R.; El-Kerdawy, M. M. New series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives: Synthesis, antitumor activity, EGFR tyrosine kinase inhibitory activity and molecular modeling studies. Med. Chem. Res. 2015, 24, 860-878.

     

    23. Gabr, M. T.; El-Gohary, N. S.; El-Bendary, E. R.; El-Kerdawy, M. M. Synthesis and in vitro antitumor activity of new series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives. Eur. J. Med. Chem. 2014, 85, 576-592.

     

    24. Gabr, M. T.; El-Gohary, N. S.; El-Bendary, E. R.; El-Kerdawy, M. M. EGFR tyrosine kinase targeted compounds: In vitro antitumor activity and molecular modeling studies of new series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives. EXCLI J. 2014, 13, 573-585.

     

    25. Qi, W.; Gabr, M. T.; Liu, Z.; Hu, L.; Hana, M.; Zhu, S.; Xu, G. Tris(2,2-bipyridyl) ruthenium(II) electrochemiluminescence of glyoxal, glyoxylic acid, methylglyoxal, and acetaldehyde. Electrochimica Acta 2013, 89, 139-143.

     

     

    Review articles and book chapters

    1. Ibrahim, M. M. and Gabr, M. T.* Multitarget therapeutic strategies for Alzheimer’s disease. Neural. Regen. Res. 2019, 14, 437-440. (* corresponding author)

     

    2. Gabr, M. T. and Pigge, F. C. Aggregation-Induced Emission: Materials and Applications Volume 1. January 1, 2016, 175-191.

  • Patents

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    1. Schultz, M. K.; Reedy, J.; Pigge, C.; Gabr, M. T.; Varmazyad M.; Goswami, P. C. Image-guided therapy of cancer. US Patent. 15/383983; filed December 19, 2016; Grant date: May 29th, 2018 .

     

    2. Schultz, M. K.; Pigge, C.; Li, M.; Gabr, M. T.; Sagastume, E. Compositions for chelating metals at low temperature. US Patent App. Serial No. 62/662,074; filed May 4th, 2018.

     

    3. Pigge, C.; Gabr, M. T. Dinuclear platinum(II) compounds and methods of use thereof. US Provisional Patent Serial No. 62/816,421; filed March 11th 2019.

  • Awards and Recognition

     

    1. University of Michigan Life Sciences Postdoctoral Fellowship 2019 (Gratefully declined).

     

     

    2. ACS Division of Inorganic Chemistry (DIC) Travel Award 2019.

     

     

    3. Lynn Anderson Research Excellence Award, University of Iowa, Spring 2018.

     

     

    4. ACS Division of Organic Chemistry (ORGN) Travel Award 2018.

     

     

    5. Ballard Seashore Dissertation Fellowship, University of Iowa, Fall 2018.

     

     

    6. University of Iowa Graduate College Fellowship in Radiochemistry, Spring and Summer 2018.

     

     

    7. Graduate College, University of Iowa Travel Award 2018.

     

     

    8. Graduate College Summer Fellowship, University of Iowa, Summer 2017.

     

     

    9. Outstanding Teaching Award, Department of Chemistry, University of Iowa, Spring 2017.

     

     

    10. University of Iowa Graduate College Fellowship in Radiochemistry, Summer 2015.

     

     

    11. Distinguished Master’s Thesis Award in Mansoura University for 2014/2015.

     

     

    12. RSC Travel Award to 3rd RSC Young Members Symposium. University of Birmingham, UK, June 2014.

     

     

    13. University of Jena Travel Award to JCF spring symposium 2014.

     

     

    14. Participants Prize in 7th PG Symposium on Biological and Medicinal Chemistry, Cambridge, UK, Dec. 2013.

     

     

    15. Best Poster Award in “The First International Conference on New Horizons in Basic and Applied Science”, Egypt, September 2013.

     

     

    16. Egyptian Government Undergraduate Research Scholarship Spring 2011.

     

     

    17. Chinese Academy of Sciences Undergraduate Research Scholarship Summer 2010.

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